Isolierte massive Nebennieren-blutung--eine heimtuckische Komplikation der Antikoagulation. [Isolated massive adrenal hemorrhage--an insidious complication in anticoagulation]

Details

Serval ID
serval:BIB_7E0A5E149565
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Isolierte massive Nebennieren-blutung--eine heimtuckische Komplikation der Antikoagulation. [Isolated massive adrenal hemorrhage--an insidious complication in anticoagulation]
Journal
Schweizerische Rundschau fur Medizin Praxis
Author(s)
Marty  B., Maurer  R.
ISSN
1013-2058 (Print)
Publication state
Published
Issued date
04/1992
Volume
81
Number
16
Pages
524-8
Notes
English Abstract
Journal Article
Review --- Old month value: Apr 14
Abstract
Massive bilateral adrenal hemorrhages are a rare complication of anticoagulant therapy. Among over 34,000 autopsies of adults we found six patients with such hemorrhages. Two were women and four men with a mean age of 81 years. They had been hospitalized and anticoagulated for various reasons. The hemorrhage occurred within ten days of anticoagulation, was always bilateral and massive and destroyed the adrenal cortex, thus leading to acute adreno-cortical insufficiency. The diagnosis in all patients was made only at autopsy. Main symptoms are abdominal pain, progressive hypotension, electrolyte disorders and disturbances of consciousness. In patient on anticoagulant therapy, these symptoms justify the suspicion of adrenal hemorrhage and the institution of lifesaving substitution therapy. Pathogenetically these hemorrhages are attributed to the combined effects of stress-induced adrenocortical tissue damage and increased bleeding tendency. The findings in our patients are compared with those of 83 patients from the literature.
Keywords
Adrenal Cortex Diseases/*chemically induced/pathology Aged Aged, 80 and over Anticoagulants/*adverse effects Female Hemorrhage/*chemically induced/pathology Humans Male
Pubmed
Create date
28/01/2008 9:31
Last modification date
20/08/2019 14:39
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