Blood culture-based diagnosis of bacteraemia: state of the art.

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Version: Final published version
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Serval ID
serval:BIB_7DD2E41A8965
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Blood culture-based diagnosis of bacteraemia: state of the art.
Journal
Clinical Microbiology and Infection
Author(s)
Opota O., Croxatto A., Prod'hom G., Greub G.
ISSN
1469-0691 (Electronic)
ISSN-L
1198-743X
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
21
Number
4
Pages
313-322
Language
english
Notes
Publication types: <Publication Status: ppublish Document Type: Review
Abstract
Blood culture remains the best approach to identify the incriminating microorganisms when a bloodstream infection is suspected, and to guarantee that the antimicrobial treatment is adequate. Major improvements have been made in the last years to increase the sensitivity and specificity and to reduce the time to identification of microorganisms recovered from blood cultures. Among other factors, the introduction in clinical microbiology laboratories of the matrix-assisted laser desorption ionization time-of-flight mass spectrometry technology revolutionized the identification of microorganisms whereas the introduction of nucleic-acid-based methods, such as DNA hybridization or rapid PCR-based test, significantly reduce the time to results. Together with traditional antimicrobial susceptibility testing, new rapid methods for the detection of resistance mechanisms respond to major epidemiological concerns such as methicillin-resistant Staphylococcus aureus, extended-spectrum β-lactamase or carbapenemases. This review presents and discusses the recent developments in microbial diagnosis of bloodstream infections based on blood cultures.
Pubmed
Web of science
Open Access
Yes
Create date
12/06/2015 17:46
Last modification date
20/08/2019 15:39
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