Bone marrow stem cell therapy for cardiac repair: challenges and perspectives

Details

Serval ID
serval:BIB_7D89CB6DB742
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Bone marrow stem cell therapy for cardiac repair: challenges and perspectives
Journal
Minerva Cardioangiologica
Author(s)
Vassalli  G., Vanderheyden  M., Renders  F., Eeckhout  E., Bartunek  J.
ISSN
0026-4725 (Print)
Publication state
Published
Issued date
10/2007
Volume
55
Number
5
Pages
659-67
Language
english
Notes
Journal Article --- Old month value: Oct
Abstract
Bone marrow (BM) stem cells can differentiate into multiple cell types, including vascular cells and, possibly, cardiac myocytes. Stem and progenitor cells are mobilized into the peripheral circulation early after myocardial infarction. Experimental evidence suggests that BM-derived cells injected into infarcted hearts can improve cardiac function. However, mechanisms underlying functional improvements remain unclear. Initial randomized, placebo-controlled trials in patients with acute myocardial infarction have provided controversial RESULTS: On the one hand, a modest but significant and sustained improvement in left ventricular function was observed in the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) study contributing to the better clinical course. Results of other studies were neutral. Differences in the study design, cell processing or timing of cell delivery might explain, in part, different outcomes among studies. Furthermore, studies in patients with chronic ischemic heart disease remain observational, and therapeutic effects using surrogate end-points needs to be demonstrated. Thus, there is a need for further coordinated research with well designed, hypothesis-driven clinical trials, in parallel with fundamental research aimed at understanding the mechanisms underlying the biological and functional effects of BM cell therapy for cardiac repair.
Pubmed
Create date
28/01/2008 9:51
Last modification date
20/08/2019 14:38
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