Bone marrow stem cell therapy for cardiac repair: challenges and perspectives

Détails

ID Serval
serval:BIB_7D89CB6DB742
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Bone marrow stem cell therapy for cardiac repair: challenges and perspectives
Périodique
Minerva Cardioangiologica
Auteur⸱e⸱s
Vassalli  G., Vanderheyden  M., Renders  F., Eeckhout  E., Bartunek  J.
ISSN
0026-4725 (Print)
Statut éditorial
Publié
Date de publication
10/2007
Volume
55
Numéro
5
Pages
659-67
Langue
anglais
Notes
Journal Article --- Old month value: Oct
Résumé
Bone marrow (BM) stem cells can differentiate into multiple cell types, including vascular cells and, possibly, cardiac myocytes. Stem and progenitor cells are mobilized into the peripheral circulation early after myocardial infarction. Experimental evidence suggests that BM-derived cells injected into infarcted hearts can improve cardiac function. However, mechanisms underlying functional improvements remain unclear. Initial randomized, placebo-controlled trials in patients with acute myocardial infarction have provided controversial RESULTS: On the one hand, a modest but significant and sustained improvement in left ventricular function was observed in the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) study contributing to the better clinical course. Results of other studies were neutral. Differences in the study design, cell processing or timing of cell delivery might explain, in part, different outcomes among studies. Furthermore, studies in patients with chronic ischemic heart disease remain observational, and therapeutic effects using surrogate end-points needs to be demonstrated. Thus, there is a need for further coordinated research with well designed, hypothesis-driven clinical trials, in parallel with fundamental research aimed at understanding the mechanisms underlying the biological and functional effects of BM cell therapy for cardiac repair.
Pubmed
Création de la notice
28/01/2008 9:51
Dernière modification de la notice
20/08/2019 14:38
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