Supercritical fluid extraction of drugs in drug addict hair.

Details

Serval ID
serval:BIB_7D0233425AB1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Supercritical fluid extraction of drugs in drug addict hair.
Journal
Journal of Chromatography. B, Biomedical Applications
Author(s)
Cirimele V., Kintz P., Majdalani R., Mangin P.
ISSN
1572-6495[print], 1572-6495[linking]
Publication state
Published
Issued date
1995
Volume
673
Number
2
Pages
173-181
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Opiates were extracted from sixteen hair samples of drug addicts using a supercritical fluid extraction method with supercritical carbon dioxide and a modifier solution of methanol-triethylamine-water (2:2:1, v/v). the concentrations, as determined by GC-MS, ranged from 1.22 to 21.73 (mean 7.60 ng/mg), 0.17 to 1.54 (mean 0.69 ng/mg) and 0.15 to 14.009 ng/mg hair (mean 3.78 ng/mg) for codeine, morphine and 6-monoacetylmorphine, respectively. The reproducibility of the total procedure had a relative standard deviation of 13%, 17% and 14% for codeine, morphine and 6-monoacetylmorphine, respectively. But this method, concentrations of 0.3, 0.2 and 0.1 ng/mg hair for codeine, morphine and 6-monoacetylmorphine, respectively, could be detected. Relative extraction recoveries were 61%, 53% and 96% for codeine, morphine and 6-monoacetylmorphine, respectively.
Keywords
Cannabinoids/analysis, Carbon Dioxide, Cocaine/analysis, Codeine/analysis, Codeine/isolation & purification, Ethylamines, Gas Chromatography-Mass Spectrometry, Hair/chemistry, Humans, Methanol, Morphine/analysis, Morphine/isolation & purification, Morphine Derivatives/analysis, Morphine Derivatives/isolation & purification, Narcotics/isolation & purification, Opioid-Related Disorders, Reproducibility of Results, Solutions, Temperature, Water
Pubmed
Create date
19/10/2010 15:31
Last modification date
20/08/2019 14:38
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