Gene expression across mammalian organ development.

Details

Serval ID
serval:BIB_7CF7C4B1B63D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gene expression across mammalian organ development.
Journal
Nature
Author(s)
Cardoso-Moreira M., Halbert J., Valloton D., Velten B., Chen C., Shao Y., Liechti A., Ascenção K., Rummel C., Ovchinnikova S., Mazin P.V., Xenarios I., Harshman K., Mort M., Cooper D.N., Sandi C., Soares M.J., Ferreira P.G., Afonso S., Carneiro M., Turner JMA, VandeBerg J.L., Fallahshahroudi A., Jensen P., Behr R., Lisgo S., Lindsay S., Khaitovich P., Huber W., Baker J., Anders S., Zhang Y.E., Kaessmann H.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Publication state
Published
Issued date
07/2019
Peer-reviewed
Oui
Volume
571
Number
7766
Pages
505-509
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs.
Keywords
Animals, Biological Evolution, Chickens/genetics, Female, Gene Expression Regulation, Developmental, Humans, Macaca mulatta/genetics, Male, Mice, Opossums/genetics, Organogenesis/genetics, Rabbits, Rats, Transcriptome/genetics
Pubmed
Web of science
Create date
18/07/2019 18:31
Last modification date
24/09/2019 6:26
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