Transgenic mice and their impact on kidney research.

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Serval ID
serval:BIB_7BABD3B1F0E9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Transgenic mice and their impact on kidney research.
Journal
Pflügers Archiv
Author(s)
Rubera I., Hummler E., Beermann F.
ISSN
1432-2013[electronic]
Publication state
Published
Issued date
12/2009
Volume
458
Number
1
Pages
211-222
Language
english
Abstract
The kidney is a key organ in the maintenance of ion and fluid homeostasis and specific transport systems localized along the nephron guarantee this function. Due to its large functional heterogeneity, experiments on the whole organ level cannot be easily performed, and thus more refined tools are needed, like for example the development of specific recombination systems to gain knowledge on the physiological role of single proteins implicated in ion transport. This review introduces the transgenic technology developed over the past decades, and then focuses on recent strategies for generating kidney-specific gene targeting, over-expression, and gene ablation in mice, that will help to understand the physiological role of proteins implicated in salt and water balance in the kidney.
Keywords
Animals, Aquaporin 2/genetics, Disease Models, Animal, Embryonic Stem Cells/transplantation, Epithelial Sodium Channel/genetics, Genetic Engineering, Genetic Vectors/physiology, Humans, Integrases/metabolism, Kidney/physiology, Kidney Diseases/genetics, Kidney Diseases/physiopathology, Lentivirus/genetics, Mice, Mice, Knockout, Mice, Transgenic, Transgenes/physiology
Pubmed
Web of science
Open Access
Yes
Create date
18/03/2009 9:56
Last modification date
20/10/2020 14:41
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