Zika virus, vaccines, and antiviral strategies.

Details

Serval ID
serval:BIB_7B9120567621
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Zika virus, vaccines, and antiviral strategies.
Journal
Expert review of anti-infective therapy
Author(s)
Masmejan S., Baud D., Musso D., Panchaud A.
ISSN
1744-8336 (Electronic)
ISSN-L
1478-7210
Publication state
Published
Issued date
06/2018
Peer-reviewed
Oui
Volume
16
Number
6
Pages
471-483
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Zika virus (ZIKV) recently emerged as a global public health emergency of international concern. ZIKV is responsible for severe neurological complications in adults and infection during pregnancy and can lead to congenital Zika syndrome. There is no licensed vaccine or drug to prevent or treat ZIKV infection. Areas covered: The aim of this article is to provide an overview and update of the progress of research on anti-ZIKV vaccine and medications until the end of 2017, with a special emphasis on drugs that can be used during pregnancy. Expert commentary: Development of new vaccines and drugs is challenging and several points particular to ZIKV infections augment this difficulty: (1) Cross-reactions between ZIKV and other flaviviruses, the impact of ZIKV vaccination on subsequent flavivirus infections, and vice-versa, is unknown, (2) Drugs against ZIKV should be safe in pregnant women, and (3) Evaluation of the efficacy of vaccine and drugs against ZIKV in clinical trials phase II-IV will be complicated due to the decline of ZIKV circulation.
Keywords
Adult, Animals, Antiviral Agents/administration & dosage, Antiviral Agents/adverse effects, Drug Design, Female, Humans, Infectious Disease Transmission, Vertical/prevention & control, Pregnancy, Pregnancy Complications, Infectious/virology, Vaccination/methods, Viral Vaccines/administration & dosage, Zika Virus Infection/complications, Zika Virus Infection/epidemiology, Zika Virus Infection/prevention & control, Antiviral, ZIKV, arbovirus, drugs, emerging diseases, fetus, flavivirus, microcephaly, pregnancy, vaccine, zika virus
Pubmed
Web of science
Create date
25/06/2018 9:47
Last modification date
20/08/2019 15:37
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