TNF-alpha failed to reverse the M. leprae-induced defective chemiluminescence response of human mononuclear cells.

Details

Serval ID
serval:BIB_7916C10BDE13
Type
Article: article from journal or magazin.
Collection
Publications
Title
TNF-alpha failed to reverse the M. leprae-induced defective chemiluminescence response of human mononuclear cells.
Journal
FEMS Microbiology Immunology
Author(s)
Launois P., Niang M., Dieye A., Sarthou J.L.
ISSN
0920-8534 (Print)
ISSN-L
0920-8534
Publication state
Published
Issued date
1992
Volume
89
Number
2
Pages
91-96
Language
english
Abstract
The effect of phagocyte activation by TNF-alpha on the ability to trigger a chemiluminescence (CL) response, associated with the release of oxidizing species was evaluated in healthy human mononuclear cells in the presence of Mycobacterium leprae. Recombinant TNF-alpha (r-TNF-alpha) increased the CL response of unstimulated M. bovis BCG- and PMA-stimulated cells but did not reverse the M. leprae defective activation of the human phagocyte oxidative burst. M. leprae was less well phagocytosed than M. bovis BCG but phagocytosis of mycobacteria was not altered by addition of r-TNF-alpha. The failure of activation of oxygen-free radical production might have some relevance to the pathogenesis of leprosy.
Keywords
Humans, Leprosy/immunology, Leukocytes, Mononuclear/drug effects, Leukocytes, Mononuclear/immunology, Luminescent Measurements, Mycobacterium bovis/immunology, Mycobacterium leprae/immunology, Phagocytosis/drug effects, Recombinant Proteins/pharmacology, Respiratory Burst/drug effects, Tumor Necrosis Factor-alpha/pharmacology
Pubmed
Create date
28/01/2008 11:06
Last modification date
20/08/2019 14:35
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