Immunogenic chemotherapy: discovery of a critical protein through proteomic analyses of tumor cells.

Details

Serval ID
serval:BIB_78F72692CC21
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Immunogenic chemotherapy: discovery of a critical protein through proteomic analyses of tumor cells.
Journal
Cancer genomics & proteomics
Author(s)
Apetoh L., Obeid M., Tesniere A., Ghiringhelli F., Fimia G.M., Piacentini M., Kroemer G., Zitvogel L.
ISSN
1109-6535 (Print)
ISSN-L
1109-6535
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
4
Number
2
Pages
65-70
Language
english
Notes
Publication types: Journal Article ; Review; pdf review
Publication Status: ppublish
Abstract
The aim of chemotherapy and radiotherapy is to eliminate tumor cells. While the outcomes of these cytotoxic treatments have previously been assigned to their direct effects on tumor cells, recent findings have shown that the host's immune system also contributes to the success of chemotherapeutic and radiotherapeutic regimens. The finding that some cytotoxic antitumor coumpounds such as anthracyclines were capable of triggering a potent T-cell-dependent antitumor response has prompted the search for molecular determinants responsible for the immunogenicity of anthracyclines. Proteomic analyses of anthracycline-treated tumor cells have recently revealed the critical involvement of calreticulin in mediating the immunogenicity of dying tumor cells. Here, we focused on the molecular study of immunogenic chemotherapy which led to the characterization of calreticulin as a critical protein in immunogenic cancer cell death.

Keywords
Animals, Calreticulin/immunology, Calreticulin/metabolism, Cell Death, Humans, Immunotherapy, Neoplasm Proteins/immunology, Neoplasm Proteins/metabolism, Neoplasms/drug therapy, Neoplasms/immunology, Neoplasms/metabolism, Neoplasms/pathology, Proteomics/methods
Pubmed
Create date
13/09/2017 18:35
Last modification date
03/03/2018 18:30
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