Immunogenic chemotherapy: discovery of a critical protein through proteomic analyses of tumor cells.

Détails

ID Serval
serval:BIB_78F72692CC21
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Immunogenic chemotherapy: discovery of a critical protein through proteomic analyses of tumor cells.
Périodique
Cancer genomics & proteomics
Auteur(s)
Apetoh L., Obeid M., Tesniere A., Ghiringhelli F., Fimia G.M., Piacentini M., Kroemer G., Zitvogel L.
ISSN
1109-6535 (Print)
ISSN-L
1109-6535
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
4
Numéro
2
Pages
65-70
Langue
anglais
Notes
Publication types: Journal Article ; Review; pdf review
Publication Status: ppublish
Résumé
The aim of chemotherapy and radiotherapy is to eliminate tumor cells. While the outcomes of these cytotoxic treatments have previously been assigned to their direct effects on tumor cells, recent findings have shown that the host's immune system also contributes to the success of chemotherapeutic and radiotherapeutic regimens. The finding that some cytotoxic antitumor coumpounds such as anthracyclines were capable of triggering a potent T-cell-dependent antitumor response has prompted the search for molecular determinants responsible for the immunogenicity of anthracyclines. Proteomic analyses of anthracycline-treated tumor cells have recently revealed the critical involvement of calreticulin in mediating the immunogenicity of dying tumor cells. Here, we focused on the molecular study of immunogenic chemotherapy which led to the characterization of calreticulin as a critical protein in immunogenic cancer cell death.

Mots-clé
Animals, Calreticulin/immunology, Calreticulin/metabolism, Cell Death, Humans, Immunotherapy, Neoplasm Proteins/immunology, Neoplasm Proteins/metabolism, Neoplasms/drug therapy, Neoplasms/immunology, Neoplasms/metabolism, Neoplasms/pathology, Proteomics/methods
Pubmed
Création de la notice
13/09/2017 18:35
Dernière modification de la notice
03/03/2018 18:30
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