Simultaneous determination of pethidine (meperidine), phenoperidine, and norpethidine (normeperidine), their common metabolite, by gas chromatography with selective nitrogen detection.

Details

Serval ID
serval:BIB_78889E0C711B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Simultaneous determination of pethidine (meperidine), phenoperidine, and norpethidine (normeperidine), their common metabolite, by gas chromatography with selective nitrogen detection.
Journal
Forensic Science International
Author(s)
Kintz P., Godelar B., Mangin P., Lugnier A.A., Chaumont A.J.
ISSN
0379-0738[print], 0379-0738[linking]
Publication state
Published
Issued date
1989
Volume
43
Number
3
Pages
267-273
Language
english
Abstract
This article describes a selective gas chromatographic method for the resolution and quantification of phenoperidine and its two metabolites, pethidine (meperidine) and norpethidine (normeperidine). Drugs and SKF 525 A, the internal standard, are separated from plasma by solvent extraction under alkaline conditions. They are chromatographed on a 3% OV-17 Chromosorb Q glass column and detected with a nitrogen-phosphorous detector. Linearity is observed in the study range (5-200 ng/ml). No interference by endogenous substances is noted.
Keywords
Cholinesterase Inhibitors/blood, Cholinesterase Inhibitors/isolation & purification, Chromatography, Gas, Humans, Meperidine/analogs & derivatives, Meperidine/blood, Phenoperidine/blood, Phenoperidine/isolation & purification, Predictive Value of Tests
Pubmed
Create date
15/10/2010 14:31
Last modification date
20/08/2019 14:35
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