Simultaneous determination of pethidine (meperidine), phenoperidine, and norpethidine (normeperidine), their common metabolite, by gas chromatography with selective nitrogen detection.

Détails

ID Serval
serval:BIB_78889E0C711B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Simultaneous determination of pethidine (meperidine), phenoperidine, and norpethidine (normeperidine), their common metabolite, by gas chromatography with selective nitrogen detection.
Périodique
Forensic Science International
Auteur⸱e⸱s
Kintz P., Godelar B., Mangin P., Lugnier A.A., Chaumont A.J.
ISSN
0379-0738[print], 0379-0738[linking]
Statut éditorial
Publié
Date de publication
1989
Volume
43
Numéro
3
Pages
267-273
Langue
anglais
Résumé
This article describes a selective gas chromatographic method for the resolution and quantification of phenoperidine and its two metabolites, pethidine (meperidine) and norpethidine (normeperidine). Drugs and SKF 525 A, the internal standard, are separated from plasma by solvent extraction under alkaline conditions. They are chromatographed on a 3% OV-17 Chromosorb Q glass column and detected with a nitrogen-phosphorous detector. Linearity is observed in the study range (5-200 ng/ml). No interference by endogenous substances is noted.
Mots-clé
Cholinesterase Inhibitors/blood, Cholinesterase Inhibitors/isolation & purification, Chromatography, Gas, Humans, Meperidine/analogs & derivatives, Meperidine/blood, Phenoperidine/blood, Phenoperidine/isolation & purification, Predictive Value of Tests
Pubmed
Création de la notice
15/10/2010 14:31
Dernière modification de la notice
20/08/2019 14:35
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