Striking immunodominance hierarchy of naturally occurring CD8+ and CD4+ T cell responses to tumor antigen NY-ESO-1.

Details

Serval ID
serval:BIB_786275E9ADDB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Striking immunodominance hierarchy of naturally occurring CD8+ and CD4+ T cell responses to tumor antigen NY-ESO-1.
Journal
Journal of Immunology
Author(s)
Jackson H., Dimopoulos N., Mifsud N.A., Tai T.Y., Chen Q., Svobodova S., Browning J., Luescher I., Stockert L., Old L.J., Davis I.D., Cebon J., Chen W.
ISSN
0022-1767 (Print)
ISSN-L
0022-1767
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
176
Number
10
Pages
5908-5917
Language
english
Abstract
Immunodominance has been well-demonstrated in many antiviral and antibacterial systems, but much less so in the setting of immune responses against cancer. Tumor Ag-specific CD8+ T cells keep cancer cells in check via immunosurveillance and shape tumor development through immunoediting. Because most tumor Ags are self Ags, the breadth and depth of antitumor immune responses have not been well-appreciated. To design and develop antitumor vaccines, it is important to understand the immunodominance hierarchy and its underlying mechanisms, and to identify the most immunodominant tumor Ag-specific T cells. We have comprehensively analyzed spontaneous cellular immune responses of one individual and show that multiple tumor Ags are targeted by the patient's immune system, especially the "cancer-testis" tumor Ag NY-ESO-1. The pattern of anti-NY-ESO-1 T cell responses in this patient closely resembles the classical broad yet hierarchical antiviral immunity and was confirmed in a second subject.
Keywords
Animals, Antigens, Neoplasm/physiology, CD4-Positive T-Lymphocytes/immunology, CD4-Positive T-Lymphocytes/metabolism, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, CHO Cells, Cell Line, Transformed, Cell Line, Tumor, Cricetinae, Cricetulus, Epitopes, T-Lymphocyte/immunology, Epitopes, T-Lymphocyte/metabolism, Humans, Immunity, Innate, Immunodominant Epitopes/immunology, Immunodominant Epitopes/metabolism, Male, Membrane Proteins/physiology, Middle Aged
Pubmed
Web of science
Create date
28/01/2008 11:20
Last modification date
20/08/2019 14:35
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