Striking immunodominance hierarchy of naturally occurring CD8+ and CD4+ T cell responses to tumor antigen NY-ESO-1.

Détails

ID Serval
serval:BIB_786275E9ADDB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Striking immunodominance hierarchy of naturally occurring CD8+ and CD4+ T cell responses to tumor antigen NY-ESO-1.
Périodique
Journal of Immunology
Auteur(s)
Jackson H., Dimopoulos N., Mifsud N.A., Tai T.Y., Chen Q., Svobodova S., Browning J., Luescher I., Stockert L., Old L.J., Davis I.D., Cebon J., Chen W.
ISSN
0022-1767 (Print)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
176
Numéro
10
Pages
5908-5917
Langue
anglais
Résumé
Immunodominance has been well-demonstrated in many antiviral and antibacterial systems, but much less so in the setting of immune responses against cancer. Tumor Ag-specific CD8+ T cells keep cancer cells in check via immunosurveillance and shape tumor development through immunoediting. Because most tumor Ags are self Ags, the breadth and depth of antitumor immune responses have not been well-appreciated. To design and develop antitumor vaccines, it is important to understand the immunodominance hierarchy and its underlying mechanisms, and to identify the most immunodominant tumor Ag-specific T cells. We have comprehensively analyzed spontaneous cellular immune responses of one individual and show that multiple tumor Ags are targeted by the patient's immune system, especially the "cancer-testis" tumor Ag NY-ESO-1. The pattern of anti-NY-ESO-1 T cell responses in this patient closely resembles the classical broad yet hierarchical antiviral immunity and was confirmed in a second subject.
Mots-clé
Animals, Antigens, Neoplasm/physiology, CD4-Positive T-Lymphocytes/immunology, CD4-Positive T-Lymphocytes/metabolism, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, CHO Cells, Cell Line, Transformed, Cell Line, Tumor, Cricetinae, Cricetulus, Epitopes, T-Lymphocyte/immunology, Epitopes, T-Lymphocyte/metabolism, Humans, Immunity, Innate, Immunodominant Epitopes/immunology, Immunodominant Epitopes/metabolism, Male, Membrane Proteins/physiology, Middle Aged
Pubmed
Web of science
Création de la notice
28/01/2008 12:20
Dernière modification de la notice
03/03/2018 18:29
Données d'usage