TCR signaling requirements for activating T cells and for generating memory.

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Ressource 1Download: serval:BIB_783B78F0E814.P001 (319.53 [Ko])
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Serval ID
serval:BIB_783B78F0E814
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
TCR signaling requirements for activating T cells and for generating memory.
Journal
Cellular and Molecular Life Sciences
Author(s)
Zehn D., King C., Bevan M.J., Palmer E.
ISSN
1420-9071 (Electronic)
ISSN-L
1420-682X
Publication state
Published
Issued date
2012
Volume
69
Number
10
Pages
1565-1575
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
Over the last two decades the molecular and cellular mechanisms underlying T cell activation, expansion, differentiation, and memory formation have been intensively investigated. These studies revealed that the generation of memory T cells is critically impacted by a number of factors, including the magnitude of the inflammatory response and cytokine production, the type of dendritic cell [DC] that presents the pathogen derived antigen, their maturation status, and the concomitant provision of costimulation. Nevertheless, the primary stimulus leading to T cell activation is generated through the T cell receptor [TCR] following its engagement with a peptide MHC ligand [pMHC]. The purpose of this review is to highlight classical and recent findings on how antigen recognition, the degree of TCR stimulation, and intracellular signal transduction pathways impact the formation of effector and memory T cells.
Keywords
Immunologic Memory, Lymphocyte Activation, Major Histocompatibility Complex/physiology, Receptors, Antigen, T-Cell/metabolism, Signal Transduction, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Yes
Create date
28/05/2012 17:14
Last modification date
01/10/2019 6:18
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