TCR signaling requirements for activating T cells and for generating memory.

Détails

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Etat: Public
Version: Final published version
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_783B78F0E814
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
TCR signaling requirements for activating T cells and for generating memory.
Périodique
Cellular and Molecular Life Sciences
Auteur⸱e⸱s
Zehn D., King C., Bevan M.J., Palmer E.
ISSN
1420-9071 (Electronic)
ISSN-L
1420-682X
Statut éditorial
Publié
Date de publication
2012
Volume
69
Numéro
10
Pages
1565-1575
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
Over the last two decades the molecular and cellular mechanisms underlying T cell activation, expansion, differentiation, and memory formation have been intensively investigated. These studies revealed that the generation of memory T cells is critically impacted by a number of factors, including the magnitude of the inflammatory response and cytokine production, the type of dendritic cell [DC] that presents the pathogen derived antigen, their maturation status, and the concomitant provision of costimulation. Nevertheless, the primary stimulus leading to T cell activation is generated through the T cell receptor [TCR] following its engagement with a peptide MHC ligand [pMHC]. The purpose of this review is to highlight classical and recent findings on how antigen recognition, the degree of TCR stimulation, and intracellular signal transduction pathways impact the formation of effector and memory T cells.
Mots-clé
Immunologic Memory, Lymphocyte Activation, Major Histocompatibility Complex/physiology, Receptors, Antigen, T-Cell/metabolism, Signal Transduction, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/05/2012 17:14
Dernière modification de la notice
14/02/2022 7:55
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