Traitement des epilepsies réfractaires: rôle de la stimulation electrique [Treatment of pharmacoresistant epilepsy: stimulated refractoriness].

Details

Serval ID
serval:BIB_78376E7BD794
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Traitement des epilepsies réfractaires: rôle de la stimulation electrique [Treatment of pharmacoresistant epilepsy: stimulated refractoriness].
Journal
Revue Médicale Suisse
Author(s)
Rossetti A.O., Vulliémoz S.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
2012
Volume
8
Number
339
Pages
930-934
Language
french
Notes
Publication types: English Abstract ; Journal Article ; ReviewPublication Status: ppublish
Abstract
Antiepileptic drugs allow controlling seizures in 70% of patients. For the others, a presurgical work-up should be undertaken, especially if a focal seizure origin is suspected; however, only a fraction of pharmacoresistant patients will be offered resective (curative) surgery. In the last 15 years, several palliative therapies using extra- or intracranial electrical stimulations have been developed. This article presents the vagal nerve stimulation, the deep brain stimulation (targeting the mesiotemporal region or the thalamus), and the cortical stimulation "on demand". All show an overall long-term responder rate between 30-50%, but less than 5% of patients becoming seizure free. It is to hope that a better understanding of epileptogenic mechanisms and of the implicated neuronal networks will lead to an improvement of these proportions.
Keywords
Anticonvulsants/therapeutic use, Deep Brain Stimulation/methods, Deep Brain Stimulation/utilization, Drug Resistance/physiology, Electric Stimulation/methods, Epilepsy/drug therapy, Humans, Neurosurgical Procedures, Treatment Failure, Vagus Nerve Stimulation/methods, Vagus Nerve Stimulation/utilization
Pubmed
Create date
23/07/2012 16:40
Last modification date
20/08/2019 14:35
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