Teratogenic and toxic effects of alcohol ethoxylate and alcohol ethoxy sulfate surfactants on Xenopus laevis embryos and tadpoles.

Details

Serval ID
serval:BIB_77F2199FE396
Type
Article: article from journal or magazin.
Collection
Publications
Title
Teratogenic and toxic effects of alcohol ethoxylate and alcohol ethoxy sulfate surfactants on Xenopus laevis embryos and tadpoles.
Journal
Ecotoxicology and Environmental Safety
Author(s)
Cardellini P., Ometto L.
ISSN
0147-6513 (Print)
ISSN-L
0147-6513
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
48
Number
2
Pages
170-177
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The two surfactants tested, an alcohol ethoxylate (AE) and an alcohol ethoxy sulfate (AES), demonstrate both teratogenic and toxic effects in Xenopus laevis embryos and tadpoles. From acute tests and observations of malformations under light and electron microscopy, the AES produced less teratogenic and toxic effects than the AE, from which it differs only by the presence of a sulfate in the hydrophilic group of the molecule. The 72-h LC(50) was 4.59 mg/L for the AE and 6.75 g/L for the AES. The tissues most affected were the epithelia, particularly of the gills. As the AE exhibited ultrastructural alterations of mitochondria and narcotic effects, O(2) consumption was studied in treated tadpoles; results indicated collapse of the electrochemical gradient in mitochondria.
Keywords
Abnormalities, Drug-Induced/pathology, Alcohols/toxicity, Animals, Embryo, Nonmammalian/drug effects, Embryonic Development, Gills/pathology, Larva/drug effects, Larva/growth & development, Microscopy, Electron, Scanning, Morphogenesis/drug effects, Oxygen Consumption/drug effects, Sulfuric Acid Esters/toxicity, Surface-Active Agents/toxicity, Survival Rate, Teratogens/toxicity, Xenopus laevis
Pubmed
Web of science
Create date
19/11/2007 10:34
Last modification date
20/08/2019 14:34
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