Functions of peroxisome proliferator-activated receptors (PPAR) in skin homeostasis.

Details

Ressource 1Download: serval:BIB_7746765F1642.P001 (932.06 [Ko])
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Serval ID
serval:BIB_7746765F1642
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Functions of peroxisome proliferator-activated receptors (PPAR) in skin homeostasis.
Journal
Lipids
Author(s)
Di-Poï N., Michalik L., Desvergne B., Wahli W.
ISSN
0024-4201 (Print)
ISSN-L
0024-4201
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
39
Number
11
Pages
1093-1099
Language
english
Abstract
The peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors that belong to the nuclear hormone receptor family. Three isotypes (PPAR alpha, PPAR beta or delta, and PPAR gamma) with distinct tissue distributions and cellular functions have been found in vertebrates. All three PPAR isotypes are expressed in rodent and human skin. They were initially investigated for a possible function in the establishment of the permeability barrier in skin because of their known function in lipid metabolism in other cell types. In vitro studies using specific PPAR agonists and in vivo gene disruption approaches in mice indeed suggest an important contribution of PPAR alpha in the formation of the epidermal barrier and in sebocyte differentiation. The PPAR gamma isotype plays a role in stimulating sebocyte development and lipogenesis, but does not appear to contribute to epidermal tissue differentiation. The third isotype, PPAR beta, regulates the late stages of sebaceous cell differentiation, and is the most effective isotype in stimulating lipid production in these cells, both in rodents and in humans. In addition, PPAR beta activation has pro-differentiating effects in keratinocytes under normal and inflammatory conditions. Finally, preliminary studies also point to a potential role of PPAR in hair follicle growth and in melanocyte differentiation. By their diverse biological effects on cell proliferation and differentiation in the skin, PPAR agonists or antagonists may offer interesting opportunities for the treatment of various skin disorders characterized by inflammation, cell hyperproliferation, and aberrant differentiation.
Keywords
Animals, Cell Differentiation, Cell Proliferation, Homeostasis, Humans, Peroxisome Proliferator-Activated Receptors/metabolism, Skin/cytology, Skin/metabolism, Skin Diseases/metabolism, Skin Diseases/pathology
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:27
Last modification date
01/10/2019 6:18
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