The impact of DNA methylation in Alphaproteobacteria.

Details

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State: Serval
Version: Final published version
Serval ID
serval:BIB_7732682E2002
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The impact of DNA methylation in Alphaproteobacteria.
Journal
Molecular microbiology
Author(s)
Mouammine A., Collier J.
ISSN
1365-2958 (Electronic)
ISSN-L
0950-382X
Publication state
Published
Issued date
10/2018
Peer-reviewed
Oui
Volume
110
Number
1
Pages
1-10
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Alphaproteobacteria include bacteria with very different modes of life, from free-living to host-associated and pathogenic bacteria. Their genomes vary in size and organization from single circular chromosomes to multipartite genomes and are often methylated by one or more adenine or cytosine methyltransferases (MTases). These include MTases that are part of restriction/modification systems and so-called orphan MTases. The development of novel technologies accelerated the analysis of methylomes and revealed the existence of epigenetic patterns in several Alphaproteobacteria. This review describes the known functions of DNA methylation in Alphaproteobacteria and also discusses its potential drawbacks through the accidental deamination of methylated cytosines. Particular emphasis is given to the strong connection between the cell cycle-regulated orphan MTase CcrM and the complex network that controls gene expression and cell cycle progression in Alphaproteobacteria.
Keywords
Alphaproteobacteria/genetics, Alphaproteobacteria/physiology, Cell Cycle/physiology, DNA Methylation/physiology, Epigenomics, Evolution, Molecular, Gene Expression Regulation, Bacterial/genetics, Genome, Bacterial/genetics, Methyltransferases/genetics, Methyltransferases/physiology
Pubmed
Web of science
Open Access
Yes
Create date
18/07/2018 15:24
Last modification date
22/07/2019 6:12
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