Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin.

Details

Serval ID
serval:BIB_76EAEC3348E0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin.
Journal
Nano Letters
Author(s)
Alonso-Sarduy L., Longo G., Dietler G., Kasas S.
ISSN
1530-6992 (Electronic)
ISSN-L
1530-6984
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
13
Number
11
Pages
5679-5684
Language
english
Abstract
Cancer is a major health issue that absorbs the attention of a large part of the biomedical research. Intercalating agents bind to DNA molecules and can inhibit their synthesis and transcription; thus, they are increasingly used as drugs to fight cancer. In this work, we show how atomic force microscopy in liquid can characterize, through time-lapse imaging, the dynamical influence of intercalating agents on the supercoiling of DNA, improving our understanding of the drug's effect.
Keywords
DNA intercalating agents, daunorubicin, AFM, linking number, time-lapse imaging, drug development
Pubmed
Web of science
Create date
20/12/2013 12:59
Last modification date
20/08/2019 14:34
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