Retrovirus-induced target cell activation in the early phases of infection: the mouse mammary tumor virus model.

Details

Serval ID
serval:BIB_763467E00E63
Type
Article: article from journal or magazin.
Collection
Publications
Title
Retrovirus-induced target cell activation in the early phases of infection: the mouse mammary tumor virus model.
Journal
Journal of Virology
Author(s)
Ardavin C., Luthi F., Andersson M., Scarpellino L., Martin P., Diggelmann H., Acha-Orbea H.
ISSN
0022-538X (Print)
ISSN-L
0022-538X
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
71
Number
10
Pages
7295-7299
Language
english
Abstract
Mouse mammary tumor virus (MMTV) infects B lymphocytes and expresses a superantigen on the cell surface after integration of its reverse-transcribed genome. Superantigen-dependent B- and T-cell activation becomes detectable 2 to 3 days after infection. We show here that before this event, B cells undergo a polyclonal activation which does not involve massive proliferation. This first phase of B-cell activation is T cell independent. Moreover, during the first phase of activation, when only a small fraction of B cells is infected by MMTV(SW), viral DNA is detected only in activated B cells. Such a B-cell activation is also seen after injection of murine leukemia virus but not after injection of vaccinia virus, despite the very similar kinetics and intensity of the immune response. Since retroviruses require activated target cells to induce efficient infection, these data suggest that the early polyclonal retrovirus-induced target cell activation might play an important role in the establishment of retroviral infections.
Keywords
Animals, B-Lymphocytes/immunology, B-Lymphocytes/virology, DNA Replication, DNA, Viral/analysis, DNA, Viral/biosynthesis, Female, Genome, Viral, Kinetics, Lymph Nodes/immunology, Lymph Nodes/virology, Lymphocyte Activation, Mammary Neoplasms, Experimental/immunology, Mammary Neoplasms, Experimental/virology, Mammary Tumor Virus, Mouse/genetics, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Mice, Inbred Strains, Mice, Nude, Milk/virology, Retroviridae Infections/immunology, T-Lymphocytes/immunology, T-Lymphocytes/virology, Time Factors, Tumor Virus Infections/immunology, Virus Integration, Virus Replication
Pubmed
Web of science
Create date
24/01/2008 15:48
Last modification date
03/03/2018 18:25
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