Myeloid cells contribute to tumor lymphangiogenesis.

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Serval ID
serval:BIB_75C4C6E8AF12
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Myeloid cells contribute to tumor lymphangiogenesis.
Journal
PloS One
Author(s)
Zumsteg A., Baeriswyl V., Imaizumi N., Schwendener R., Rüegg C., Christofori G.
ISSN
1932-6203[electronic]
Publication state
Published
Issued date
2009
Volume
4
Number
9
Pages
e7067
Language
english
Abstract
The formation of new blood vessels (angiogenesis) and lymphatic vessels (lymphangiogenesis) promotes tumor outgrowth and metastasis. Previously, it has been demonstrated that bone marrow-derived cells (BMDC) can contribute to tumor angiogenesis. However, the role of BMDC in lymphangiogenesis has largely remained elusive. Here, we demonstrate by bone marrow transplantation/reconstitution and genetic lineage-tracing experiments that BMDC integrate into tumor-associated lymphatic vessels in the Rip1Tag2 mouse model of insulinoma and in the TRAMP-C1 prostate cancer transplantation model, and that the integrated BMDC originate from the myelomonocytic lineage. Conversely, pharmacological depletion of tumor-associated macrophages reduces lymphangiogenesis. No cell fusion events are detected by genetic tracing experiments. Rather, the phenotypical conversion of myeloid cells into lymphatic endothelial cells and their integration into lymphatic structures is recapitulated in two in vitro tube formation assays and is dependent on fibroblast growth factor-mediated signaling. Together, the results reveal that myeloid cells can contribute to tumor-associated lymphatic vessels, thus extending the findings on the previously reported role of hematopoietic cells in lymphatic vessel formation.
Pubmed
Web of science
Open Access
Yes
Create date
08/01/2010 14:58
Last modification date
20/08/2019 14:33
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