Acute hepatitis with prolonged cholestasis and disappearance of interlobular bile ducts following tibolone and Hypericum perforatum (St. John's wort). Case of drug interaction?
Details
Serval ID
serval:BIB_757A33D4D4D3
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Acute hepatitis with prolonged cholestasis and disappearance of interlobular bile ducts following tibolone and Hypericum perforatum (St. John's wort). Case of drug interaction?
Journal
Acta Gastro-enterologica Belgica
ISSN
0001-5644 (Print)
ISSN-L
0001-5644
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
71
Number
1
Pages
36-38
Language
english
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Abstract
The case of a patient under tibolone therapy for two years who developed a mixed-type liver injury with prolonged cholestasis and features of the vanishing bile duct syndrome following a ten weeks treatment with St. John wort (Hypericum Perforatum) infusions is reported. In the absence of evidence of a potential role for concomitant medication i.e. hydroxychloroquine sulfate to play a role in the clinical, biochemical and morphological picture, an interaction between the herbal preparation and tibolone was suspected as the likely cause of liver damage.
Keywords
Androgen Antagonists/adverse effects, Bile Ducts, Intrahepatic/drug effects, Bile Ducts, Intrahepatic/pathology, Cholestasis/chemically induced, Drug Interactions, Drug-Induced Liver Injury/etiology, Female, Humans, Hypericum/adverse effects, Middle Aged, Norpregnenes/adverse effects, Postmenopause
Pubmed
Web of science
Create date
19/01/2015 12:15
Last modification date
20/08/2019 15:32