Meningococcal disease in a kidney transplant recipient with mannose-binding lectin (MBL) deficiency
Details
Serval ID
serval:BIB_754FE5F3037A
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Meningococcal disease in a kidney transplant recipient with mannose-binding lectin (MBL) deficiency
Title of the conference
12th International Society for infectious Diseases
Address
Lisbon, Portugal, June 15-18, 2006
ISBN
1201-9712
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
10
Series
International Journal of Infectious Diseases
Pages
S16
Language
english
Notes
Publication type : Meeting Abstract
Abstract
Background: There is an increasing amount of
data associating MBL deficiency with a higher susceptibility
to meningococca[ disease. In addition,
meningococca[ disease has been reported in patients
with various immunosuppressive conditions.
However, to our knowledge, only three cases of
meningococca[ disease have been reported in solid
organ recipients (SOT).
Methods & Results: A 32 year-old male patient underwent
cadaveric kidney transplantation for endstage
renal disease of unknown origin. On day 71
post-transplantation he developed fever (39.6°C),
shaking chilis, and tachycardia without hypotension.
At this time, immunosuppression consisted
of tacro[imus, prednisone 10mg daily and mycopheno[
ate mofeti[ 2 g daily. Physical examination
on admission was normal, except for two small
petechia[ lesions on the forearm. No meningeal
signs were present. Three sets of blood cultures
grew Neisseria meningitidis group C susceptible to
ceftriaxone (MIC=0.003mg/[). Antibiotic therapy
consisted in intravenous ceftriaxone 2 g per day for
a total duration of 7 days. Serum immunog[obu[in
levels, C3, C4 and CHS0 were normal However, using
a method to screen for the functional activity of
a[[ three pathways of complement (Wies[ab, Lund,
Sweden), no activation via the MBL pathway could
be detected (0%). A subsequent quantification of
MBL pathway components revealed normal levels
of MASP 2 but undetectab[e amounts of MBL (below
10 ng/m[, normal range: >500 ng/m[).
Conclusion: Since the exact incidence and the possible
relationship between meningococca[ disease
and organ transplantation is not we[[ understood,
we strongly encourage transplantation centers to
report additional cases. The potential clinical usefu[
ness of screening SOT candidates for MBL deficiency
in relation to infectious complications after
transplantation remains to be determined.
data associating MBL deficiency with a higher susceptibility
to meningococca[ disease. In addition,
meningococca[ disease has been reported in patients
with various immunosuppressive conditions.
However, to our knowledge, only three cases of
meningococca[ disease have been reported in solid
organ recipients (SOT).
Methods & Results: A 32 year-old male patient underwent
cadaveric kidney transplantation for endstage
renal disease of unknown origin. On day 71
post-transplantation he developed fever (39.6°C),
shaking chilis, and tachycardia without hypotension.
At this time, immunosuppression consisted
of tacro[imus, prednisone 10mg daily and mycopheno[
ate mofeti[ 2 g daily. Physical examination
on admission was normal, except for two small
petechia[ lesions on the forearm. No meningeal
signs were present. Three sets of blood cultures
grew Neisseria meningitidis group C susceptible to
ceftriaxone (MIC=0.003mg/[). Antibiotic therapy
consisted in intravenous ceftriaxone 2 g per day for
a total duration of 7 days. Serum immunog[obu[in
levels, C3, C4 and CHS0 were normal However, using
a method to screen for the functional activity of
a[[ three pathways of complement (Wies[ab, Lund,
Sweden), no activation via the MBL pathway could
be detected (0%). A subsequent quantification of
MBL pathway components revealed normal levels
of MASP 2 but undetectab[e amounts of MBL (below
10 ng/m[, normal range: >500 ng/m[).
Conclusion: Since the exact incidence and the possible
relationship between meningococca[ disease
and organ transplantation is not we[[ understood,
we strongly encourage transplantation centers to
report additional cases. The potential clinical usefu[
ness of screening SOT candidates for MBL deficiency
in relation to infectious complications after
transplantation remains to be determined.
Keywords
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Web of science
Create date
05/01/2011 10:59
Last modification date
20/08/2019 14:32