Uric acid transport and disease.

Details

Serval ID
serval:BIB_74F7918F742F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Uric acid transport and disease.
Journal
Journal of Clinical Investigation
Author(s)
So A., Thorens B.
ISSN
1558-8238[electronic], 0021-9738[linking]
Publication state
Published
Issued date
2010
Volume
120
Number
6
Pages
1791-1799
Language
english
Abstract
Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant properties that may be protective but can also be pro-oxidant, depending on its chemical microenvironment. Hyperuricemia predisposes to disease through the formation of urate crystals that cause gout, but hyperuricemia, independent of crystal formation, has also been linked with hypertension, atherosclerosis, insulin resistance, and diabetes. We discuss here the biology of urate metabolism and its role in disease. We also cover the genetics of urate transport, including URAT1, and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development.
Keywords
Animals, Biological Transport/genetics, Glucose Transport Proteins, Facilitative/genetics, Glucose Transport Proteins, Facilitative/metabolism, Gout/etiology, Gout/genetics, Humans, Hypertension/complications, Hypertension/genetics, Hyperuricemia/etiology, Hyperuricemia/genetics, Uric Acid/blood, Uric Acid/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
23/06/2010 12:49
Last modification date
20/08/2019 14:32
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