High prevalence of major cardiovascular risk factors in first-degree relatives of individuals with familial premature coronary artery disease--the GENECARD project.

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State: Public
Version: author
Serval ID
serval:BIB_74EBDB7045E0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
High prevalence of major cardiovascular risk factors in first-degree relatives of individuals with familial premature coronary artery disease--the GENECARD project.
Journal
Atherosclerosis
Author(s)
Hurrell C., Wietlisbach V., Jotterand V., Volet M., Lenain V., Nicod P., Darioli R., Paccaud F., Waeber G., Mooser V.
ISSN
1879-1484[electronic]
ISSN-L
0021-9150
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
194
Number
1
Pages
253-264
Language
english
Abstract
BACKGROUND: Hypertension, hypercholesterolemia, obesity and smoking are highly prevalent among patients with familial premature coronary artery disease (FP-CAD). Whether these risk factors equally affect other family members remains unknown. METHODS: We examined 222 FP-CAD patients, 158 unaffected sibs, 197 offspring and 94 spouses in 108 FP-CAD families (> or = 2 sibs having survived CAD diagnosed before age 51 (M)/56 (F)), and compared them to population controls. RESULTS: Unaffected sibs had a higher prevalence of hypertension (49% versus 24%, p<0.001), hypercholesterolemia (47% versus 34%, p=0.002), abdominal obesity (35% versus 24%, p=0.006) and smoking (39% versus 24%, p=0.001) than population controls. Offspring had a higher prevalence of hypertension (females), hypercholesterolemia and abdominal obesity than population controls. No difference was observed between spouses and controls. Compared to unaffected sibs, FP-CAD affected sibs had a similar risk factor profile, except for smoking, which was more prevalent (76% versus 39%, p=0.008). CONCLUSIONS: Hypertension, obesity and hypercholesterolemia are highly prevalent among first-degree relatives, but not spouses, of patients with FP-CAD. These persons deserve special medical attention due to their familial/genetic susceptibility to atherogenic metabolic abnormalities. In these families, smoking may be the trigger for FP-CAD.
Keywords
Abdominal Fat, Adult, Adult Children, Age of Onset, Body Mass Index, Coronary Artery Disease, Family, Female, Genetic Predisposition to Disease, Humans, Hypercholesterolemia, Hypertension, Male, Middle Aged, Obesity, Prevalence, Risk Factors, Siblings, Smoking, Spouses
Pubmed
Web of science
Create date
17/11/2008 8:57
Last modification date
20/08/2019 14:32
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