Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis.

Eperon, S.; Sauty, A.; Lanz, R.; Leimgruber, A.; Lurati, F.; Guex-Crosier, Y.

doi:10.1007/s00417-004-0943-6

Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis.

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Serval ID

serval:BIB_74A347CC425D

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis.

Journal

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie

Author(s)

Eperon S., Sauty A., Lanz R., Leimgruber A., Lurati F., Guex-Crosier Y.

ISSN

0721-832X

Publication state

Published

Issued date

2004

Peer-reviewed

Oui

Volume

242

Number

Pages

966-70

Language

english

Notes

Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish

Abstract

PURPOSE: To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season. METHODS: Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five SAC patients showing a strong sensitivity to grass pollen (skin-prick tests and specific serum IgE) were collected both in season and out of season. ELISA measured eotaxin-1 level. RESULTS: Eotaxin-1 concentration in tears of SAC patients [2,100+/-503 (SEM) pg/ml] and normal subjects (1,193+/-176 pg/ml) were significantly different (P=0.0049). Regarding allergic patients, the clinical score (sum of five allergic criteria) was significantly different in season and out of season (P=0.0043) as was also the case with eotaxin-1 concentration (P=0.024). CONCLUSIONS: The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy.

Keywords

Adult, Chemokine CCL11, Chemokines, CC, Chemotactic Factors, Eosinophil, Conjunctivitis, Allergic, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Prospective Studies, Seasons, Tears, Up-Regulation

URN

urn:nbn:ch:serval-BIB_74A347CC425D1

OAI-PMH

oai:serval.unil.ch:BIB_74A347CC425D

DOI

10.1007/s00417-004-0943-6

Pubmed

15221302

Web of science

000225973300011

Open Access

Yes