Cien Años de Microglía: Milestones in a Century of Microglial Research.

Details

Serval ID
serval:BIB_747FD90BE2C6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Cien Años de Microglía: Milestones in a Century of Microglial Research.
Journal
Trends in neurosciences
Author(s)
Sierra A., Paolicelli R.C., Kettenmann H.
ISSN
1878-108X (Electronic)
ISSN-L
0166-2236
Publication state
Published
Issued date
11/2019
Peer-reviewed
Oui
Volume
42
Number
11
Pages
778-792
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The year 2019 marks the 100-year anniversary of the discovery of microglia by Pío del Río-Hortega. We will recount the state of neuroscience research at the beginning of the 20th century and the heated scientific dispute regarding microglial identity. We will then walk through some of the milestones of microglial research in the decades since then. In the last 20 years, the field has grown exponentially. Researchers have shown that microglia are unlike any other resident macrophages: they have a unique origin and distinguishing features. Microglia are extraordinarily motile cells and constantly survey their environment, interacting with neurons, astrocytes, oligodendrocytes, neural stem cells, and infiltrating immune cells. We finally highlight some open questions for future research regarding microglia's identity, population dynamics, and dual (beneficial and detrimental) role in pathology.
Keywords
Cajal, Hortega, Virchow, brain macrophages, history, microglia, neuroinflammation
Pubmed
Web of science
Open Access
Yes
Create date
24/10/2019 15:34
Last modification date
15/07/2020 5:26
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