Cien Años de Microglía: Milestones in a Century of Microglial Research.
Détails
![Ressource 1](https://serval.unil.ch/static/img/forbidden.png)
Accès restreint UNIL
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_747FD90BE2C6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Cien Años de Microglía: Milestones in a Century of Microglial Research.
Périodique
Trends in neurosciences
ISSN
1878-108X (Electronic)
ISSN-L
0166-2236
Statut éditorial
Publié
Date de publication
11/2019
Peer-reviewed
Oui
Volume
42
Numéro
11
Pages
778-792
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
The year 2019 marks the 100-year anniversary of the discovery of microglia by Pío del Río-Hortega. We will recount the state of neuroscience research at the beginning of the 20th century and the heated scientific dispute regarding microglial identity. We will then walk through some of the milestones of microglial research in the decades since then. In the last 20 years, the field has grown exponentially. Researchers have shown that microglia are unlike any other resident macrophages: they have a unique origin and distinguishing features. Microglia are extraordinarily motile cells and constantly survey their environment, interacting with neurons, astrocytes, oligodendrocytes, neural stem cells, and infiltrating immune cells. We finally highlight some open questions for future research regarding microglia's identity, population dynamics, and dual (beneficial and detrimental) role in pathology.
Mots-clé
Cajal, Hortega, Virchow, brain macrophages, history, microglia, neuroinflammation
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/10/2019 16:34
Dernière modification de la notice
23/02/2023 7:53