Relevance of animal models to the prophylaxis of infective endocarditis.
Details
Serval ID
serval:BIB_73E1386089B8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Relevance of animal models to the prophylaxis of infective endocarditis.
Journal
Journal of Antimicrobial Chemotherapy
ISSN
0305-7453 (Print)
ISSN-L
0305-7453
Publication state
Published
Issued date
09/1987
Peer-reviewed
Oui
Volume
20 Suppl A
Pages
87-98
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Intravascular or cardiac endothelial lesions may become colonized during bacteraemic episodes and lead to the development of bacterial endocarditis (BE). It has therefore long been recommended that patients with known cardiac lesions receive prophylactic antibiotics before undergoing procedures that might release bacteria into the blood stream. Because clinical trials of antibiotic prophylaxis of endocarditis cannot be conducted in humans for ethical as well as for statistical reasons (Durack, 1985), the questions of which antibiotic, what dosage, and for how long are a matter of controversy. Unfortunately, these questions can only be studied in animals, with all the limitations that this type of approach brings with it. However, animal experimental studies have helped in understanding the conditions and, to some extent, the mode of action of antibiotics in preventing the development of endocardial infection, thus allowing some rationale for devising prophylactic recommendations for the various patients at risk of developing BE.
Keywords
Animals, Anti-Bacterial Agents/therapeutic use, Cardiac Catheterization, Disease Models, Animal, Endocarditis, Bacterial/prevention & control, Humans, Rabbits, Rats
Pubmed
Web of science
Create date
25/01/2008 18:07
Last modification date
20/08/2019 15:31