Growth arrest-specific gene 6 » (Gas6) as an intra-hospital mortality predictor for patients in septic shock

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Ressource 1Download: BIB_73B8CCDB91FE.P001.pdf (10735.80 [Ko])
State: Public
Version: After imprimatur
Serval ID
serval:BIB_73B8CCDB91FE
Type
A Master's thesis.
Publication sub-type
Master (thesis) (master)
Collection
Publications
Title
Growth arrest-specific gene 6 » (Gas6) as an intra-hospital mortality predictor for patients in septic shock
Author(s)
Kosinski Ch.
Director(s)
Angelillo-Scherrer A.
Institution details
Université de Lausanne, Faculté de biologie et médecine
Publication state
Accepted
Issued date
2011
Language
english
Number of pages
26
Abstract
Aim: Gas6 is known to be elevated in sepsis, correlating with the severity of infection and¦organ failure. We aimed to investigate the performance of Gas6 plasma levels at¦admission to predict the risk of mortality in a cohort of septic patients.¦Methods: We used prospectively collected data and plasma samples from the "Sepsis¦Cohorte Romande". Gas6 level was measured by ELISA at admission and expressed in¦percentage relative to its level in a pool of normal plasma.¦Results: Non-survivors (n=21) presented higher Gas6 levels than survivors (n=73) (median¦258% vs 164%, IQR 194 and 117 respectively) (p=0.0027). Gas6 correlated positively with¦different cytokines and was the best mortality predictor, as shown by the ROC curves area.¦In patients with septic shock (n=66), using 249% as a cut-off value, Gas6 measurement¦had a specificity of 67% and a sensitivity of 81% for predicting mortality. ROC curve area¦was 0.75. Positive and negative predictive values were 57% and 87%, respectively.¦Conclusion: Thus, Gas6 plasma level at admission might be a useful tool to predict¦mortality in patients with septic shock. Although Gas6 hold promise as an early sepsis¦marker, its precise implication in sepsis remains to be elucidated. Our observation should¦be further investigated in larger prospective clinical trials.
Keywords
Gas6, sepsis, human, mortality predictor
Create date
21/05/2012 11:15
Last modification date
20/08/2019 15:31
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