Endothelial function, mechanical stress and atherosclerosis.

Details

Serval ID
serval:BIB_733D9457A849
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Endothelial function, mechanical stress and atherosclerosis.
Journal
Advances in Cardiology
Author(s)
Hayoz D., Mazzolai L.
ISSN
0065-2326
Publication state
Published
Issued date
2007
Volume
44
Pages
62-75
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Atherosclerosis and its complications represent the leading cause of morbidity and mortality in the industrialized as well as in the developing countries. Classical cardiovascular risk factors have been identified over the past decades leading to recommendations for life style modifications and to the development of efficient and well-tolerated drug regimens aimed at reducing the occurrence of cardiovascular complications. The endothelium due to its position in the circulation is the first organ being exposed to circulating noxious elements and solutes as well as to the mechanical aggressions generated by heartbeats and pulsating blood flow. This review addresses the relevance of the combined effects of the mechanical stress and cardiovascular risk factors on the early phases of atherosclerosis.
Keywords
Age Factors, Atherosclerosis/metabolism, Atherosclerosis/physiopathology, Blood Flow Velocity, Blood Pressure, Endothelium, Vascular/metabolism, Endothelium, Vascular/physiopathology, Humans, Nitric Oxide/metabolism, Pulsatile Flow, Risk Factors, Stress, Mechanical, Vascular Resistance
Pubmed
Web of science
Create date
17/01/2008 16:38
Last modification date
20/08/2019 14:31
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