BRAF-mutated carcinomas among thyroid nodules with prior indeterminate FNA report: a systematic review and meta-analysis.

Details

Serval ID
serval:BIB_72E64AFE2205
Type
Article: article from journal or magazin.
Collection
Publications
Title
BRAF-mutated carcinomas among thyroid nodules with prior indeterminate FNA report: a systematic review and meta-analysis.
Journal
Clinical Endocrinology
Author(s)
Trimboli P., Treglia G., Condorelli E., Romanelli F., Crescenzi A., Bongiovanni M., Giovanella L.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
84
Number
3
Pages
315-320
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
BACKGROUND: Several molecular analyses have been investigated for risk stratification of thyroid nodules, with a particular focus on the V600E mutation of the BRAF gene [BRAF(V600E)]. To date, there is no high-level evidence supporting or refuting a role for BRAF analysis in thyroid nodules with prior indeterminate cytology. To obtain more robust evidence, we reviewed and meta-analysed data from published articles.
RESEARCH DESIGN AND METHODS: A comprehensive literature search of the PubMed/MEDLINE, Embase and Scopus databases was conducted using the terms 'BRAF', 'thyroid' and 'indeterminate'. The search was updated until March 2015, and references of the retrieved articles were also screened. Only original articles reporting BRAF mutation testing within nodules with indeterminate FNA were eligible for inclusion.
RESULTS: The literature search revealed 82 articles, of which 8 were eligible for the study. Five studies were prospective and three retrospective. The majority of authors analysed BRAF mutations in FNA samples which were classified by the British or Bethesda system. Of the initial series of studies, a pooled number of 1361 cases were achieved of which 43 were BRAF mutated. Overall, the BRAF mutation rate was 4·6% (95% CI: 1-10·8%), ranging from 0 to 22·9%. When we included only histological series, 978 thyroid nodules were found. Of these, 245 were cancers.
CONCLUSIONS: A very low rate of lesions with indeterminate cytology are BRAF mutated. Thus, the role of this biomarker to detect or exclude cancers in patients with such FNA reports is marginal and should be reconsidered in guidelines.
Pubmed
Web of science
Open Access
Yes
Create date
29/04/2015 13:57
Last modification date
08/05/2019 20:23
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