Individual Classification of Mild Cognitive Impairment Subtypes by Support Vector Machine Analysis of White Matter DTI.

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State: Public
Version: author
Serval ID
serval:BIB_72C1026C3D11
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Individual Classification of Mild Cognitive Impairment Subtypes by Support Vector Machine Analysis of White Matter DTI.
Journal
Ajnr. American Journal of Neuroradiology
Author(s)
Haller S., Missonnier P., Herrmann F.R., Rodriguez C., Deiber M.P., Nguyen D., Gold G., Lovblad K.O., Giannakopoulos P.
ISSN
1936-959X (Electronic)
ISSN-L
0195-6108
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
34
Number
2
Pages
283-291
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
BACKGROUND AND PURPOSE: MCI was recently subdivided into sd-aMCI, sd-fMCI, and md-aMCI. The current investigation aimed to discriminate between MCI subtypes by using DTI.
MATERIALS AND METHODS: Sixty-six prospective participants were included: 18 with sd-aMCI, 13 with sd-fMCI, and 35 with md-aMCI. Statistics included group comparisons using TBSS and individual classification using SVMs.
RESULTS: The group-level analysis revealed a decrease in FA in md-aMCI versus sd-aMCI in an extensive bilateral, right-dominant network, and a more pronounced reduction of FA in md-aMCI compared with sd-fMCI in right inferior fronto-occipital fasciculus and inferior longitudinal fasciculus. The comparison between sd-fMCI and sd-aMCI, as well as the analysis of the other diffusion parameters, yielded no significant group differences. The individual-level SVM analysis provided discrimination between the MCI subtypes with accuracies around 97%. The major limitation is the relatively small number of cases of MCI.
CONCLUSIONS: Our data show that, at the group level, the md-aMCI subgroup has the most pronounced damage in white matter integrity. Individually, SVM analysis of white matter FA provided highly accurate classification of MCI subtypes.
Pubmed
Web of science
Open Access
Yes
Create date
18/02/2013 10:41
Last modification date
20/08/2019 14:30
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