The SLC2 family of facilitated hexose and polyol transporters.

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Serval ID
serval:BIB_72AB04FFF9E9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The SLC2 family of facilitated hexose and polyol transporters.
Journal
Pflügers Archiv : European Journal of Physiology
Author(s)
Uldry M., Thorens B.
ISSN
0031-6768[print], 0031-6768[linking]
Publication state
Published
Issued date
2004
Volume
447
Number
5
Pages
480-489
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The SLC2 family of glucose and polyol transporters comprises 13 members, the glucose transporters (GLUT) 1-12 and the H(+)- myo-inositol cotransporter (HMIT). These proteins all contain 12 transmembrane domains with both the amino and carboxy-terminal ends located on the cytoplasmic side of the plasma membrane and a N-linked oligosaccharide side-chain located either on the first or fifth extracellular loop. Based on sequence comparison, the GLUT isoforms can be grouped into three classes: class I comprises GLUT1-4; class II, GLUT6, 8, 10, and 12 and class III, GLUT5, 7, 9, 11 and HMIT. Despite their sequence similarity and the presence of class-specific signature sequences, these transporters carry various hexoses and HMIT is a H(+)/ myo-inositol co-transporter. Furthermore, the substrate transported by some isoforms has not yet been identified. Tissue- and cell-specific expression of the well-characterized GLUT isoforms underlies their specific role in the control of whole-body glucose homeostasis. Numerous studies with transgenic or knockout mice indeed support an important role for these transporters in the control of glucose utilization, glucose storage and glucose sensing. Much remains to be learned about the transport functions of the recently discovered isoforms (GLUT6-13 and HMIT) and their physiological role in the metabolism of glucose, myo-inositol and perhaps other substrates.
Keywords
Animals, Biological Transport/physiology, Hexoses/metabolism, Humans, Monosaccharide Transport Proteins/physiology, Multigene Family/physiology, Polymers/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 13:41
Last modification date
01/10/2019 6:18
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