Laminar specificity of intrinsic connections in Broca's area.

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Serval ID
serval:BIB_72A5F5754BED
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Laminar specificity of intrinsic connections in Broca's area.
Journal
Cerebral Cortex
Author(s)
Tardif E., Probst A., Clarke S.
ISSN
1460-2199[electronic]
Publication state
Published
Issued date
2007
Volume
17
Number
12
Pages
2949-2960
Language
english
Notes
Journal article --- Old month value: Mar 29
Abstract
Broca's area and its right hemisphere homologue comprise 2 cytoarchitectonic subdivisions, FDgamma and FCBm of von Economo C and Koskinas GN (1925, Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen. Vienna/Berlin [Germany]: Springer). We report here on intrinsic connections within these areas, as revealed with biotinylated dextran amine and 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate tracing in postmortem human brains. Injections limited to supragranular layers revealed a complex intrinsic network of horizontal connections within layers II and III spreading over several millimeters and to a lesser extent within layers IV, V, and VI. Ninety percent of the retrogradely labeled neurons (n = 734) were in supragranular layers, 4% in layer IV, and 6% in infragranular layers; most were pyramids and tended to be grouped into clusters of approximately 500 microm in diameter. Injections involving layer IV revealed extended horizontal connections within layers I-IV (up to 3.7 mm) and to a lesser extent in layers V and VI. Injections limited to the infragranular layers revealed horizontal connections mainly limited to these layers. Thus, intrinsic connections within Broca's area display a strong laminar specificity. This pattern is very similar in areas FDgamma and FCBm and in the 2 hemispheres.
Keywords
Aged, Aged, 80 and over, Female, Frontal Lobe, Humans, Male, Nerve Net, Neural Pathways
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 11:34
Last modification date
25/09/2019 6:09
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