Biphasic saturations of binding proteins can be the result of a competitive inhibition of substrate fixation

Details

Serval ID
serval:BIB_728BBD89E47A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Biphasic saturations of binding proteins can be the result of a competitive inhibition of substrate fixation
Journal
Biochimie
Author(s)
Gaudin  C., Marty  B., Ragot  M., Sari  J. C., Belaich  J. P.
ISSN
0300-9084 (Print)
Publication state
Published
Issued date
1978
Volume
60
Number
4
Pages
353-9
Notes
Journal Article
Abstract
A mathematical model is proposed which explains some biphasic saturations of Binding Proteins by their substrates through an effect of a competitive inhibition. The inhibitor can be the substrate itself especially when the retention phenomenon is occuring. This model has been verified with two periplasmic Binding Proteins of Escherichia coli: the Glutamine Binding Protein and the Leucine-Isoleucine-Valine Binding Protein. A significant connection is found between experimental results and the hypothesis.
Keywords
Binding, Competitive *Carrier Proteins/metabolism Escherichia coli/metabolism Glutamine Kinetics Mathematics Models, Chemical Oligopeptides Protein Binding
Pubmed
Web of science
Create date
28/01/2008 10:31
Last modification date
20/08/2019 15:30
Usage data