Dietary vitamin D and cancers of the oral cavity and esophagus.

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_7256230DC865
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dietary vitamin D and cancers of the oral cavity and esophagus.
Journal
Annals of Oncology
Author(s)
Lipworth Loren, Rossi Marta, McLaughlin Joseph K., Negri Eva, Talamini Renato, Levi Fabio, Franceschi Silvia, La Vecchia Carlo
ISSN
1569-8041[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
20
Number
9
Pages
1576-1581
Language
english
Abstract
BACKGROUND: Data on the association between vitamin D and upper digestive tract neoplasms are limited. METHODS: In two case-control studies in Italy, we examined the relation between dietary vitamin D intake and squamous cell carcinoma of the esophagus (SCCE; 304 cases) and oral/pharyngeal cancer (804 cases). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by multiple logistic regression. RESULTS: Adjusted ORs for SCCE and oral/pharyngeal cancer were 0.58 (95% CI 0.39-0.86) and 0.76 (95% CI 0.60-0.94), respectively, for the highest tertile of vitamin D intake. Using a reference group of those in the highest tertile of vitamin D who were never/former smokers, ORs were 8.7 (95% CI 4.1-18.7) for SCCE and 10.4 (95% CI 6.9-15.5) for oral/pharyngeal cancer among heavy smokers in the lowest vitamin D tertile; similarly, compared with those in the highest tertile of vitamin D who drank <3 alcoholic drinks/day, corresponding ORs were 41.9 (95% CI 13.7-128.6) for SCCE and 8.5 (95% CI 5.7-12.5) for oral/pharyngeal cancer, among heavy alcohol drinkers in the lowest vitamin D tertile. CONCLUSION: We observed inverse associations between dietary vitamin D intake and risk of SCCE and, perhaps, oral/pharyngeal cancer, which were most pronounced among heavy current smokers and heavy consumers of alcohol.
Keywords
Adult, Aged, Alcohol Drinking/adverse effects, Case-Control Studies, Diet, Esophageal Neoplasms/epidemiology, Female, Humans, Incidence, Male, Middle Aged, Mouth Neoplasms/epidemiology, Odds Ratio, Smoking/adverse effects, Vitamin D/administration & dosage, Vitamins/administration & dosage
Pubmed
Web of science
Open Access
Yes
Create date
04/02/2010 16:37
Last modification date
25/09/2019 6:09
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