Nouvelles thérapies pour les maladies osseuses de l'enfant [New therapies for children affected by bone diseases].

Details

Serval ID
serval:BIB_7253090BCD83
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nouvelles thérapies pour les maladies osseuses de l'enfant [New therapies for children affected by bone diseases].
Journal
Revue Médicale Suisse
Author(s)
Ballhausen D., Dépraz N.G., Kern I., Unger S., Bonafé L.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
2012
Volume
8
Number
329
Pages
398-402
Language
french
Notes
Publication types: English Abstract ; Journal Article Publication Status: ppublish
Abstract
Considerable progress has been achieved in recent years in treating children affected by bone diseases. Advances in the understanding of the molecular pathophysiology of genetic bone diseases have led to the development of enzyme replacement therapies for various lysosomal storage diseases, following the breakthrough initiated in treating Gaucher disease. Clinical studies are underway with tailored molecules correcting bone fragility and alleviating chronic bone pain and other manifestations of hypophosphatasia, or promoting growth of long bones in achondroplasia patients. We further report our very encouraging experience with intravenous bisphosphonate treatment in children suffering from secondary osteopenia and the high prevalence of calcium and vitamin D deficits in these severely disabled children.
Keywords
Bone Diseases/drug therapy, Child, Humans
Pubmed
Create date
06/06/2012 18:06
Last modification date
20/08/2019 14:30
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