FMRP and its target RNAs: fishing for the specificity.

Details

Serval ID
serval:BIB_72330E11E8AF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
FMRP and its target RNAs: fishing for the specificity.
Journal
Neuroreport
Author(s)
Veneri M., Zalfa F., Bagni C.
ISSN
0959-4965 (Print)
ISSN-L
0959-4965
Publication state
Published
Issued date
15/11/2004
Volume
15
Number
16
Pages
2447-2450
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Learning and memory difficulties observed in patients with fragile X syndrome, as well as in a mouse model for the syndrome, are partially due to impaired translational regulation of neuronal mRNAs encoding key molecules for the synaptic structure and function. There has been intense interest in characterizing the mRNAs that are regulated by the fragile X mental retardation protein (FMRP) in the neuronal cell. A large number of candidate FMRP-interacting mRNAs has been identified over the last few years and three models have been described so far to explain the specificity of these interactions. Here, we report our vision on how they could work in the same and/or in different pathways and suggest that the three mechanisms may not be mutually exclusive.

Keywords
Animals, Fragile X Mental Retardation Protein, Humans, MicroRNAs/metabolism, Models, Molecular, Nerve Tissue Proteins/metabolism, RNA, Messenger/metabolism, RNA-Binding Proteins/metabolism
Pubmed
Create date
06/03/2017 17:23
Last modification date
20/08/2019 14:30
Usage data