Histone H1 regulates chromatin condensation in Leishmania parasites.

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Version: author
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Serval ID
serval:BIB_721FF45AC3A7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Histone H1 regulates chromatin condensation in Leishmania parasites.
Journal
Experimental Parasitology
Author(s)
Masina S., Zangger H., Rivier D., Fasel N.
ISSN
0014-4894 (Print)
ISSN-L
0014-4894
Publication state
Published
Issued date
2007
Volume
116
Number
1
Pages
83-87
Language
english
Abstract
We investigated the functional role of the Leishmania histone H1 and demonstrate for the first time that addition of histone H1 has a strong effect on microccocal digestion, chromatin condensation of parasite nuclei and that its overexpression can modulate parasite infectivity in vivo.
Keywords
Animals, Cell Line, Chromatin/metabolism, Gene Expression, Histones/genetics, Histones/physiology, Leishmania major/chemistry, Leishmania major/pathogenicity, Leishmaniasis, Cutaneous/parasitology, Macrophages/parasitology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Signal Transduction, Transfection, Virulence
Pubmed
Web of science
Create date
24/01/2008 15:02
Last modification date
19/08/2020 5:22
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