Clinical studies with a vascular vasopressin antagonist.

Details

Serval ID
serval:BIB_708D2466F3A7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical studies with a vascular vasopressin antagonist.
Journal
Journal of cardiovascular pharmacology
Author(s)
Waeber B., Nussberger J., Hofbauer K.G., Nicod P., Brunner H.R.
ISSN
0160-2446
Publication state
Published
Issued date
1986
Peer-reviewed
Oui
Volume
8 Suppl 7
Pages
S111-6
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
The effect of circulating arginine vasopressin (AVP) on blood pressure, heart rate, and skin blood flow was assessed in normotensive subjects, mild hypertensive patients, and patients with congestive heart failure, utilizing the specific antagonist of AVP at the vascular receptor level, d(CH2)5Tyr(Me)AVP (5 micrograms/kg i.v.). The renin system of the normal volunteers treated with the AVP antagonist was either intact or acutely blocked with the angiotensin converting-enzyme inhibitor captopril (25 mg p.o.). In some volunteers, the cardiovascular effect of AVP released by Finnish sauna or cigarette smoking was studied. In patients with congestive heart failure, hemodynamic measurements (pressures and cardiac output) were obtained invasively. Acute blockade of AVP vascular receptors produced no cardiovascular effect unless plasma AVP levels were markedly elevated. In our experience, abnormally high circulating AVP appears to be responsible for the decrease in skin blood flow induced by cigarette smoking and to some extent for the maintenance of vascular tone in the rare patients with particularly severe congestive heart failure.
Keywords
Angiotensin II, Arginine Vasopressin, Heart Failure, Hemodynamics, Humans, Hypertension, Smoking, Steam Bath, Vasopressins
Pubmed
Web of science
Create date
25/01/2008 14:00
Last modification date
20/08/2019 14:29
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