The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo

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State: Public
Version: Final published version
Serval ID
serval:BIB_6F17D7494A33
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
Journal
Journal of Clinical Investigation
Author(s)
Doganci A., Eigenbrod T., Krug N., De Sanctis G. T., Hausding M., Erpenbeck V. J., Haddad e., Lehr H. A., Schmitt E., Bopp T., Kallen K. J., Herz U., Schmitt S., Luft C., Hecht O., Hohlfeld J. M., Ito H., Nishimoto N., Yoshizaki K., Kishimoto T., Rose-John S., Renz H., Neurath M. F., Galle P. R., Finotto S.
ISSN
0021-9738 (Print)
Publication state
Published
Issued date
2005
Volume
115
Number
2
Pages
313-325
Language
english
Notes
PT - Journal Article PT
Abstract
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 receptor (mIL-6R) or the soluble IL-6 receptor (sIL-6R) and glycoprotein 130 (gp130). In this study, we investigated the role of IL-6R components in asthma. We observed increased levels of sIL-6R in the airways of patients with allergic asthma as compared to those in controls. In addition, local blockade of the sIL-6R in a murine model of late-phase asthma after OVA sensitization by gp130-fraction constant led to suppression of Th2 cells in the lung. By contrast, blockade of mIL-6R induced local expansion of Foxp3-positive CD4+CD25+ Tregs with increased immunosuppressive capacities. CD4+CD25+ but not CD4+
Keywords
Adult/Animals/Antibodies/administration & dosage/immunology/Asthma/Pathology/DNA-Binding Proteins/Female/Forkhead Transcription Factors/Homeodomain Proteins/genetics/Humans/Hypersensitivity/Inflammation/Lung/Male/Mice/Mice,Knockout/Ovalbumin/metabolism/Receptors,Cytokine/Receptors,Interleukin-2/Receptors,Interleukin-6/STAT3 Transcription Factor/Signal Transduction/drug effects/Th2 Cells/Trans-Activators
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 18:36
Last modification date
20/08/2019 14:28
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