HIV-1 Subtype Is an Independent Predictor of Reverse Transcriptase Mutation K65R in HIV-1 Patients Treated with Combination Antiretroviral Therapy Including Tenofovir.

Details

Serval ID
serval:BIB_6DF464658A62
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
HIV-1 Subtype Is an Independent Predictor of Reverse Transcriptase Mutation K65R in HIV-1 Patients Treated with Combination Antiretroviral Therapy Including Tenofovir.
Journal
Antimicrobial Agents and Chemotherapy
Author(s)
Theys K., Vercauteren J., Snoeck J., Zazzi M., Camacho R.J., Torti C., Schülter E., Clotet B., Sönnerborg A., De Luca A., Grossman Z., Struck D., Vandamme A.M., Abecasis A.B.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
2013
Volume
57
Number
2
Pages
1053-1056
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways.
Pubmed
Web of science
Open Access
Yes
Create date
21/02/2013 17:44
Last modification date
20/08/2019 14:27
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