HIV-1 Subtype Is an Independent Predictor of Reverse Transcriptase Mutation K65R in HIV-1 Patients Treated with Combination Antiretroviral Therapy Including Tenofovir.
Details
Serval ID
serval:BIB_6DF464658A62
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
HIV-1 Subtype Is an Independent Predictor of Reverse Transcriptase Mutation K65R in HIV-1 Patients Treated with Combination Antiretroviral Therapy Including Tenofovir.
Journal
Antimicrobial Agents and Chemotherapy
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
2013
Volume
57
Number
2
Pages
1053-1056
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways.
Pubmed
Web of science
Open Access
Yes
Create date
21/02/2013 18:44
Last modification date
20/08/2019 15:27
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