Fluoxetine addition to methadone in addicts: pharmacokinetic aspects.
Details
Serval ID
serval:BIB_6D3FB791D7AF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fluoxetine addition to methadone in addicts: pharmacokinetic aspects.
Journal
Therapeutic Drug Monitoring
ISSN
0163-4356 (Print)
ISSN-L
0163-4356
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
18
Number
5
Pages
570-572
Language
english
Notes
Publication types: Case Reports ; Comparative Study ; Journal ArticlePublication Status: ppublish
Abstract
We report nine cases where fluoxetine (FX) (20 mg/day) was added to maintenance treatment with methadone (MTD) (dose range: 30-100 mg) in addicts with affective disorders. MTD plasma levels were measured before and after treatment with FX under steady-state conditions. Among the nine patients, two also received fluvoxamine (FLVX) at different times. Although it is possible that in some patients a moderate FX-MTD interaction occurs, resulting in increased plasma levels of MTD, this interaction is certainly less marked than that between FLVX and MTD and unlikely to have clinical consequences.
Keywords
Adult, Analgesics, Opioid/pharmacokinetics, Antidepressive Agents, Second-Generation/pharmacokinetics, Drug Interactions, Female, Fluoxetine/administration & dosage, Fluoxetine/pharmacokinetics, Fluvoxamine/administration & dosage, Fluvoxamine/pharmacokinetics, Humans, Male, Methadone/administration & dosage, Methadone/pharmacokinetics, Mood Disorders/blood, Mood Disorders/drug therapy, Serotonin Uptake Inhibitors/pharmacokinetics, Substance-Related Disorders/blood, Substance-Related Disorders/rehabilitation
Pubmed
Web of science
Create date
01/03/2013 11:39
Last modification date
20/08/2019 15:26
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