Article: article from journal or magazin.
Fluoxetine addition to methadone in addicts: pharmacokinetic aspects.
Therapeutic Drug Monitoring
Publication types: Case Reports ; Comparative Study ; Journal ArticlePublication Status: ppublish
We report nine cases where fluoxetine (FX) (20 mg/day) was added to maintenance treatment with methadone (MTD) (dose range: 30-100 mg) in addicts with affective disorders. MTD plasma levels were measured before and after treatment with FX under steady-state conditions. Among the nine patients, two also received fluvoxamine (FLVX) at different times. Although it is possible that in some patients a moderate FX-MTD interaction occurs, resulting in increased plasma levels of MTD, this interaction is certainly less marked than that between FLVX and MTD and unlikely to have clinical consequences.
Adult, Analgesics, Opioid/pharmacokinetics, Antidepressive Agents, Second-Generation/pharmacokinetics, Drug Interactions, Female, Fluoxetine/administration & dosage, Fluoxetine/pharmacokinetics, Fluvoxamine/administration & dosage, Fluvoxamine/pharmacokinetics, Humans, Male, Methadone/administration & dosage, Methadone/pharmacokinetics, Mood Disorders/blood, Mood Disorders/drug therapy, Serotonin Uptake Inhibitors/pharmacokinetics, Substance-Related Disorders/blood, Substance-Related Disorders/rehabilitation
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