Daptomycin for highly resistant Enterococcus faecium infection.
Details
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State: Public
Version: Final published version
State: Public
Version: Final published version
Serval ID
serval:BIB_6C0D260F056D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Daptomycin for highly resistant Enterococcus faecium infection.
Journal
Swiss medical weekly
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
26/06/2012
Peer-reviewed
Oui
Volume
142
Pages
w13603
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
We report a case series of 11 patients with severe E. faecium infections treated with daptomycin. All strains were resistant to ampicillin (MIC >8 mg/l), but susceptible to vancomycin. Seven out of 11 strains were also highly resistant to gentamicin (MIC >500 mg/l). All patients were treated with multiple broad-spectrum antibiotics prior to isolation of E. faecium and had severe underlying diseases. Our experience suggests that salvage therapy with daptomycin might be a safe and efficacious treatment for E. faecium infections.
Keywords
Aged, Aged, 80 and over, Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents/therapeutic use, Bacteremia/drug therapy, Daptomycin/pharmacology, Daptomycin/therapeutic use, Drug Resistance, Bacterial, Drug Therapy, Combination, Enterococcus faecium/drug effects, Enterococcus faecium/isolation & purification, Female, Humans, Male, Microbial Sensitivity Tests, Middle Aged
Pubmed
Web of science
Open Access
Yes
Create date
23/07/2012 10:42
Last modification date
20/08/2019 15:26