Daptomycin for highly resistant Enterococcus faecium infection.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_6C0D260F056D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Daptomycin for highly resistant Enterococcus faecium infection.
Journal
Swiss medical weekly
Author(s)
Rosin C., Bernsmeier C., Entenza J.M., Moreillon P., Frei R., Weisser M., Flückiger U.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
26/06/2012
Peer-reviewed
Oui
Volume
142
Pages
w13603
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
We report a case series of 11 patients with severe E. faecium infections treated with daptomycin. All strains were resistant to ampicillin (MIC >8 mg/l), but susceptible to vancomycin. Seven out of 11 strains were also highly resistant to gentamicin (MIC >500 mg/l). All patients were treated with multiple broad-spectrum antibiotics prior to isolation of E. faecium and had severe underlying diseases. Our experience suggests that salvage therapy with daptomycin might be a safe and efficacious treatment for E. faecium infections.

Keywords
Aged, Aged, 80 and over, Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents/therapeutic use, Bacteremia/drug therapy, Daptomycin/pharmacology, Daptomycin/therapeutic use, Drug Resistance, Bacterial, Drug Therapy, Combination, Enterococcus faecium/drug effects, Enterococcus faecium/isolation & purification, Female, Humans, Male, Microbial Sensitivity Tests, Middle Aged
Pubmed
Web of science
Open Access
Yes
Create date
23/07/2012 10:42
Last modification date
20/08/2019 15:26
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